谈一场变革：位点特异性重组酶对小鼠遗传分析的影响
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.
作者信息
Branda Catherine S, Dymecki Susan M
机构信息
Harvard Medical School, Department of Genetics, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
出版信息
Dev Cell. 2004 Jan;6(1):7-28. doi: 10.1016/s1534-5807(03)00399-x.
Abstract
Site-specific recombinase systems (Cre-loxP, Flp-FRT, and phi C31-att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.
摘要
位点特异性重组酶系统（Cre-loxP、Flp-FRT和phi C31-att）正在改变小鼠的正向和反向遗传学。通过在体外或体内诱导高保真DNA修饰，这些系统引发了一波新的生物学浪潮，推进了我们对基因功能、遗传关系、发育和疾病的理解。
Zotero 插件