Tang Wan-zhong, Xia Yu-jun
Department of Traumatology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Jan;24(1):75-8.
To study the immunohistochemical changes of nuclear factor-kappaBP65 (NF-kappaBp65) in human brain glioma (HBG) and human brain metastatic carcinoma (HBMC) and the role of NF-kappaBP65 in the biological behavior of the tumors.
The protein expression of NF-kappaBP65 were examined with SABC immunohistochemical technique in 18 HBG, 12 HBMC and 6 normal brain tissue samples, and the correlation between the expression and the biological behavior of the tumors was analyzed.
Normal brain tissues had only trace expression of NF-kappaBP65, whereas all tumor tissues examined expressed NF-kappaBP65. The level of NF-kappaBP65 in high-grade HBG, HBMC and recurrent HBG tissues was considerably higher than that in low-grade HBG tissues (PLT;0.01).
NF-kappaBP65 expression is associated with the malignant progression, invasion and angiogenesis of HBG and HBMC, and it may play a crucial role in the recurrence of HBG.
研究核因子-κB p65（NF-κBp65）在人脑胶质瘤（HBG）和人脑转移癌（HBMC）中的免疫组化变化以及NF-κBp65在肿瘤生物学行为中的作用。
采用SABC免疫组化技术检测18例HBG、12例HBMC和6例正常脑组织样本中NF-κBp65的蛋白表达，并分析其表达与肿瘤生物学行为之间的相关性。
正常脑组织中NF-κBp65仅有微量表达，而所有检测的肿瘤组织均表达NF-κBp65。高级别HBG、HBMC及复发性HBG组织中NF-κBp65水平显著高于低级别HBG组织（P<0.01）。
NF-κBp65表达与HBG和HBMC的恶性进展、侵袭及血管生成相关，且可能在HBG复发中起关键作用。
