Sannier K, Dompmartin A, Gallet B, Comoz F, Labbé D, Penven K, Leroy D
Service de Dermatologie, CHU de Caen.
Ann Dermatol Venereol. 2003 Nov;130(11):1047-50.
We report an unusual atrophic involution of juvenile xanthogranulomas.
A newborn boy presented with 5 papular, nodular and necrotic lesions located on the upper part of the body. The diameter of the lesions ranged between 1 and 3 cm. Light microscopy showed an infiltrate with foamy and Touton cells. Langerhans' cell histiocytosis was eliminated because none of these cells showed reactivity for S100 protein and CD1a. At the age of 8 years, all the lesions had spontaneously regressed leaving unusual atrophic scars that had the same size as the active lesions.
We compared the clinical, histological and evolution data of our patient with 251 published cases. The most significant clinical feature of juvenile xanthogranuloma is the spontaneous involution without any trace. However, hyperpigmentation, anetoderma or atrophy may occur. Atrophy is not frequent and can result from 2 mechanisms. Inflammation of the hypodermic tissue, which becomes atrophic and atrophy that may also result from collagen remodeling anomalies during the scarring process.
我们报告了一例青少年黄色肉芽肿不寻常的萎缩性 involution。
一名男婴出生时身体上部有5个丘疹、结节和坏死性病变。病变直径在1至3厘米之间。光镜检查显示有泡沫细胞和 Touton 细胞浸润。由于这些细胞均未显示对 S100 蛋白和 CD1a 的反应性，排除了朗格汉斯细胞组织细胞增多症。8岁时，所有病变均自发消退，留下与活动性病变大小相同的不寻常萎缩性瘢痕。
我们将该患者的临床、组织学和演变数据与251例已发表病例进行了比较。青少年黄色肉芽肿最显著的临床特征是自发消退且不留任何痕迹。然而，可能会出现色素沉着过度、皮肤松弛症或萎缩。萎缩并不常见，可能由两种机制导致。皮下组织炎症导致萎缩，以及瘢痕形成过程中胶原重塑异常也可能导致萎缩。
