Klemke Claus-Detlev, Held Bjsrn, Dippel Edgar, Goerdt Sergij
Department of Dermatology,Venereology,and Allergology,University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany.
J Dtsch Dermatol Ges. 2007 Jan;5(1):30-3. doi: 10.1111/j.1610-0387.2007.06154.x.
Juvenile xanthogranulomas are a rare disease entity within the spectrum of cutaneous non-Langerhans cell histiocytoses characterized by single or multiple cutaneous xanthogranulomas without further organ involvement. A 16-year-old girl developed multiple xanthogranulomas in various skin regions, especially the trunk and the flexural areas, over a period of 6 months. The clinical diagnosis was confirmed by H&E histology, showing a histiocytic infiltrate admixed with foam cells and Touton giant cells, and by immunohistochemistry using anti-bodies to stabilin-1 whose expression is highly specific for cutaneous non-Langerhans cell histiocytoses. No diabetes insipidus, pituitary hyperplasia or paraproteinemia were observed. Skin lesions were treated with a CO(2) laser and did not reappear during a 5 years follow-up period.
青少年黄色肉芽肿是皮肤非朗格汉斯细胞组织细胞增多症谱系中的一种罕见疾病实体，其特征为单个或多个皮肤黄色肉芽肿，无其他器官受累。一名16岁女孩在6个月内于身体各部位，尤其是躯干和屈侧部位出现了多个黄色肉芽肿。通过苏木精-伊红（H&E）组织学检查确诊，显示组织细胞浸润并伴有泡沫细胞和图顿巨细胞，同时通过使用抗稳定素-1抗体的免疫组织化学检查确诊，该抗体的表达对皮肤非朗格汉斯细胞组织细胞增多症具有高度特异性。未观察到尿崩症、垂体增生或副蛋白血症。皮肤病变采用二氧化碳激光治疗，在5年随访期内未复发。
