Rodríguez A M, Palou A
Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain.
Int J Obes Relat Metab Disord. 2004 Feb;28(2):327-9. doi: 10.1038/sj.ijo.0802579.
The members of the uncoupling protein family have different purported functions, which can be either directly or indirectly related to the control of body weight. In this sense, a great part of the studies carried out on this topic have been made using male subjects, although different works with male and female subjects have shown important sex-associated differences in the regulation of these proteins; for instance, sex differences have been shown in the cold-, diet- and overweight-induced expression of brown adipose tissue UCP1 and also in the correlation of muscle UCP3 with overweight. In these kinds of studies, models of obesity such as the cafeteria diet feeding and postcafeteria have been very useful. Moreover, sex hormones have been shown to modulate UCP1 expression in brown adipocytes in vitro. All of these sex-dependent differences, as well as sex differences in body weight gain under a hypercaloric diet, could be related to the different respective biological functions of male and female subjects and taking into account the gender effect in future studies on obesity could be of interest.
解偶联蛋白家族成员具有不同的假定功能，这些功能可能直接或间接与体重控制相关。从这个意义上说，尽管针对男性和女性受试者的不同研究表明在这些蛋白质的调节方面存在重要的性别相关差异，但关于这一主题的大部分研究都是使用男性受试者进行的；例如，在棕色脂肪组织UCP1的寒冷、饮食和超重诱导表达中以及肌肉UCP3与超重的相关性中都显示出了性别差异。在这类研究中，诸如自助餐饮食喂养和自助餐饮食后等肥胖模型非常有用。此外，已表明性激素在体外可调节棕色脂肪细胞中UCP1的表达。所有这些性别依赖性差异，以及高热量饮食下体重增加的性别差异，可能与男性和女性受试者各自不同的生物学功能有关，并且在未来关于肥胖的研究中考虑性别效应可能会很有意义。
