Urciuoli Paolo, Ghinassi Sabrina, Iavarone Claudio, Peparini Nadia, D'Orazi Valerio, Gabatel Riccardo, Pichelli Daniele, Iachetta Roberto Paolo, Custureri Filippo
Dipartimento di Scienze Chirurgiche, Università La Sapienza, Viale Regina Elena, 324, 00161 Roma.
Chir Ital. 2003 Nov-Dec;55(6):835-40.
We report our experience over the past 10 years in the treatment of thyroid anaplastic carcinoma analysing retrospectively 21 cases of surgical treatment (7 total thyroidectomies, 12 partial resection of the tumours and 2 biopsies). We consider the prognosis, which is invariably fatal, with no survival at 19 months and a mean survival of only 9 months, and assess the validity of a combined therapeutic approach (surgery + radiotherapy + chemotherapy) to increase survival and, above all, the patient's quality of life. The importance is stressed of through monitoring of risk factors consisting in concomitant or previous benign or malignant thyroid disease, considering total thyroidectomy to be necessary in principle for any variety of thyroid cancer. Lastly, we examine the survival trend in terms of residual disease and the presence or otherwise of remote metastases.
我们报告过去10年中治疗甲状腺未分化癌的经验,回顾性分析21例手术治疗病例(7例全甲状腺切除术、12例肿瘤部分切除术和2例活检)。我们考虑了预后,其必然是致命的,19个月时无存活病例,平均生存期仅9个月,并评估了联合治疗方法(手术+放疗+化疗)提高生存率以及最重要的患者生活质量的有效性。强调了通过监测包括伴发或既往良性或恶性甲状腺疾病在内的风险因素的重要性,原则上认为对于任何类型的甲状腺癌全甲状腺切除术都是必要的。最后,我们根据残留疾病以及远处转移的有无来研究生存趋势。