Serra-Mestres J, Ring H A, Costa D C, Gacinovic S, Walker Z, Lees A J, Robertson M M, Trimble M R
Department of Neuropsychiatry, Institute of Neurology, University College London, UK.
Acta Psychiatr Scand. 2004 Feb;109(2):140-6. doi: 10.1111/j.0001-690x.2004.00214.x.
To investigate dopamine transporter binding in Gilles de la Tourette syndrome (GTS) with SPECT and [123I]FP-CIT.
Ten neuroleptic naïve/free patients with GTS, and 10 age- and gender-matched normal volunteers were studied. Subjects were clinically evaluated. GTS severity and affective symptoms were measured and the presence of GTS-related behaviours were recorded.
The GTS group showed significantly higher binding in both caudate and putamen nuclei than the controls. No associations were found between striatal binding ratios and measures of affect or GTS-related behaviours.
Patients with GTS show higher striatal binding of FP-CIT to the striatum in comparison with age- and gender-matched control subjects, indicating that dopamine transporter abnormalities are involved in the pathophysiology of GTS. These abnormalities appear to be distributed across both caudate and putamen.
采用单光子发射计算机断层扫描（SPECT）及[123I]FP-CIT研究抽动秽语综合征（GTS）患者的多巴胺转运体结合情况。
对10例未使用过抗精神病药物的GTS患者及10名年龄和性别匹配的正常志愿者进行研究。对受试者进行临床评估，测量GTS严重程度和情感症状，并记录GTS相关行为的存在情况。
GTS组尾状核和壳核的结合均显著高于对照组。纹状体结合率与情感或GTS相关行为指标之间未发现相关性。
与年龄和性别匹配的对照受试者相比，GTS患者的纹状体对FP-CIT的结合更高，表明多巴胺转运体异常参与了GTS的病理生理过程。这些异常似乎分布在尾状核和壳核。
