Malison R T, McDougle C J, van Dyck C H, Scahill L, Baldwin R M, Seibyl J P, Price L H, Leckman J F, Innis R B
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
Am J Psychiatry. 1995 Sep;152(9):1359-61. doi: 10.1176/ajp.152.9.1359.
The authors examined whether subjects with Tourette's disorder have greater than normal striatal dopamine transporter densities, as suggested by previous post-mortem findings.
Single photon emission computed tomography (SPECT) and [123I]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123I]beta-CIT) were used to assess dopamine transporter levels in five adult patients with Tourette's disorder and five age- and gender-matched healthy comparison subjects.
Striatal [123I]beta-CIT binding was a mean of 37% (range = 6%-79%) higher in the subjects with Tourette's disorder than in the comparison subjects, and each Tourette's disorder patient had a higher level than his or her paired comparison subject.
These findings corroborate post-mortem results and support the hypothesis of a dysregulation in presynaptic dopamine function in Tourette's disorder.
正如先前尸检结果所提示的，作者研究了患有图雷特氏症的受试者纹状体多巴胺转运体密度是否高于正常水平。
使用单光子发射计算机断层扫描（SPECT）和[123I]2β-甲氧羰基-3β-（4-碘苯基）托烷（[123I]β-CIT）来评估5名患有图雷特氏症的成年患者以及5名年龄和性别匹配的健康对照受试者的多巴胺转运体水平。
患有图雷特氏症的受试者纹状体[123I]β-CIT结合水平比对照受试者平均高37%（范围为6%-79%），且每位图雷特氏症患者的水平均高于其配对的对照受试者。
这些发现证实了尸检结果，并支持图雷特氏症中突触前多巴胺功能失调的假说。
