Fernández-Aceñero María Jesús, Zamora Elena, Borbujo Jesús
Department of Surgical Pathology, Hospital General de Móstoles, c/Hilarión Eslava 28 6o-A, 28015 Madrid, Spain.
Dermatol Surg. 2003 Dec;29(12):1225-6. doi: 10.1111/j.1524-4725.2003.29392.x.
Hyaluronic acid (HA) (Restylane and Hylaform) is becoming more widely used for cosmetic procedures such as lip augmentation and treatment of facial skin lines, as other products, mainly bovine collagen, have proved allergenic in many patients.
To report a case of a 48-year-old woman who developed discrete nodules in the lips after HA injection for lip augmentation. The histologic analysis revealed the presence of a granulomatous reaction surrounding a blue amorphous material with the tinctorial features of HA.
To our knowledge, this is the third case of granulomatous body reaction against this substance, which was allegedly inert in humans. Although rare, this reaction can have important aesthetic implications, and the patients should be informed about their risks.
透明质酸（HA）（瑞蓝和海魅）在诸如丰唇和治疗面部皱纹等美容手术中应用越来越广泛，因为其他产品，主要是牛胶原蛋白，已被证明在许多患者中具有致敏性。
报告一例48岁女性在注射HA进行丰唇后唇部出现散在结节的病例。组织学分析显示，在一种具有HA染色特征的蓝色无定形物质周围存在肉芽肿反应。
据我们所知，这是第三例针对该物质的肉芽肿性身体反应病例，该物质据称对人体无活性。尽管这种反应罕见，但可能具有重要的美学意义，应告知患者相关风险。
