Shahrabi Farahani Shokoufeh, Sexton John, Stone Jeffrey D, Quinn Kevin, Woo Sook-Bin
Harvard School of Dental Medicine, 49 Worthington Street #7, Boston, MA 02120, USA.
Head Neck Pathol. 2012 Mar;6(1):16-20. doi: 10.1007/s12105-011-0304-9. Epub 2011 Oct 8.
Many dermal fillers have been used for reducing facial skin lines and for providing lip augmentation, and hyaluronic acid (HA) is one of the most widely used agents. One of the main commercial forms of HA is Restylane (Q Med, Sweden) produced by microbiological engineering techniques. Although HA is non-immunogenic, hypersensitivity and Granulomatous foreign body reactions have been reported. Herein, we report three female patients (average age 56 years) who presented with firm nodular lesions of the lip and a history of injection with HA (Restylane, Q Med, Sweden). Histopathologically, all cases showed pools of amorphous hematoxyphilic material surrounded by bands of densely collagenized connective tissue with no inflammation or foreign body reaction. Histochemical stains confirmed the presence of acid mucopolysaccharides such as hyaluronic acid. We conclude HA (Restylane, Q Med, Sweden) is an inert filler that may persist at an injection site, resulting in a tumor-like nodule.
许多真皮填充剂已被用于减少面部皮肤皱纹和丰唇，透明质酸（HA）是使用最广泛的制剂之一。HA的主要商业形式之一是通过微生物工程技术生产的瑞蓝（Q Med，瑞典）。尽管HA无免疫原性，但已有超敏反应和肉芽肿性异物反应的报道。在此，我们报告3例女性患者（平均年龄56岁），她们唇部出现坚实的结节性病变，并有注射HA（瑞蓝，Q Med，瑞典）的病史。组织病理学上，所有病例均显示无定形嗜酸性物质池，周围是致密胶原化结缔组织带，无炎症或异物反应。组织化学染色证实存在酸性粘多糖，如透明质酸。我们得出结论，HA（瑞蓝，Q Med，瑞典）是一种惰性填充剂，可能会在注射部位持续存在，导致肿瘤样结节。
