Murphy S M, Hamilton C J, Davies M L, Tighe B J
Speciality Materials Research Group, Aston University, Birmingham, UK.
Biomaterials. 1992;13(14):979-90. doi: 10.1016/0142-9612(92)90148-h.
Hydrogels, particularly the tough, low water content materials, have potential advantages in the field of clinical biosensors because of their established use as medical polymers. The factors that control transport behaviour in these polymers are discussed with particular reference to ion selectivity. The nature of the transport behaviour in relation to coated wire electrode performance is presented and an extension of these permselectivity studies to the fabrication of miniaturized devices, such as ISFETs, is described. Linear soluble hydrogel polymers, coated on to sensor substrates, may be converted to insoluble membranes using solid photosensitive aromatic monomers, such as N-vinyl carbazole. Photolithographic patterning is achieved using a UV source together with appropriate masking, followed by an oxygen plasma etch process. Gas plasma etching, which selectively removes uncross-linked (masked) areas forms the basis of an all dry, low-temperature patterning process capable of giving micrometre-scale resolution. This novel photographic process, which does not damage or extract enzymes or ionophores, can advantageously be extended to the fabrication of poly(vinylchloride)-based membranes.
水凝胶，尤其是坚韧的、低含水量的材料，由于其作为医用聚合物的既定用途，在临床生物传感器领域具有潜在优势。本文讨论了控制这些聚合物中传输行为的因素，并特别提及了离子选择性。阐述了传输行为与涂覆线电极性能的关系，并描述了将这些选择性渗透研究扩展到制造小型化器件（如离子敏感场效应晶体管）的情况。涂覆在传感器基板上的线性可溶性水凝胶聚合物，可以使用固体光敏芳香族单体（如N-乙烯基咔唑）转化为不溶性膜。使用紫外线源和适当的掩膜实现光刻图案化，随后进行氧等离子体蚀刻工艺。气体等离子体蚀刻选择性地去除未交联（被掩膜）的区域，形成了一种全干式、低温图案化工艺的基础，该工艺能够实现微米级分辨率。这种新颖的光刻工艺不会损坏或提取酶或离子载体，可有利地扩展到基于聚氯乙烯的膜的制造。
