Stempniak B, Guzek J W
Department of Pathophysiology, University School of Medicine, Lódź, Japan.
Exp Clin Endocrinol. 1990 Sep;96(1):91-5. doi: 10.1055/s-0029-1210993.
Rats dehydrated up to four days were given intracerebroventricularly insulin in a daily dose of 100 ng. Insulin decreased significantly the hypothalamic and neurohypophysial oxytocin content in euhydrated rats. In dehydrated animals the oxytocin activity in the hypothalamo-neurohypophysial system, markedly depleted after deprivation of water, could be further reduced by intracerebroventricular treatment with insulin. These results seem to suggest a possible regulatory role of brain insulin in the mechanisms of oxytocin release.
给脱水长达四天的大鼠脑室内注射每日剂量为100纳克的胰岛素。胰岛素显著降低了水分充足大鼠下丘脑和神经垂体的催产素含量。在脱水动物中，缺水后下丘脑-神经垂体系统中催产素活性明显降低，脑室内注射胰岛素可使其进一步降低。这些结果似乎表明脑胰岛素在催产素释放机制中可能具有调节作用。
