Lopez-Gonzalez Jose Sullivan, Cristerna-Sanchez Lissete, Vazquez-Manriquez Maria Eugenia, Jimenez-Orci Gonzalo, Aguilar-Cazares Dolores
Departmentos de Enfermedades Cronico Degenerativas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, mexico.
Otolaryngol Head Neck Surg. 2004 Jan;130(1):89-93. doi: 10.1016/j.otohns.2003.09.003.
We studied the participation of beta-catenin in the histologic differentiation of laryngeal squamous cell carcinomas.
At the National Institute of Respiratory Diseases, a tertiary referral center, localization and level of expression of beta-catenin were compared between normal epithelium (15 cases) and primary tumors in different degrees of differentiation (38 cases), using an immunohistochemical procedure.
Cell membrane staining of beta-catenin was observed in normal epithelium and in well and moderately differentiated carcinomas. Cytoplasmic redistribution was observed in poorly differentiated carcinomas. Loss of beta-catenin correlated with tumor dedifferentiation.
Reduction of cell membrane beta-catenin expression correlated with tumor dedifferentiation.
Loss of beta-catenin may lead to diminishing the strength of the intercellular adhesion system, thereby promoting the invasive phenotype of the squamous cell carcinoma of the larynx.
我们研究了β-连环蛋白在喉鳞状细胞癌组织学分化中的作用。
在国家呼吸系统疾病研究所（一家三级转诊中心），采用免疫组织化学方法，比较了15例正常上皮组织和38例不同分化程度原发性肿瘤中β-连环蛋白的定位和表达水平。
在正常上皮组织以及高分化和中分化癌中观察到β-连环蛋白的细胞膜染色。在低分化癌中观察到细胞质重新分布。β-连环蛋白的缺失与肿瘤去分化相关。
细胞膜β-连环蛋白表达的降低与肿瘤去分化相关。
β-连环蛋白的缺失可能导致细胞间粘附系统强度降低，从而促进喉鳞状细胞癌的侵袭性表型。
