Huang Wen-Tsung, Chen Tsai-Yun, Su Wu-Chou, Yen Chia-Jui, Tsao Chao-Jung
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital College of Medicine, 138, Sheng-Li Rd., Tainan 704, Taiwan, Republic of China.
Support Care Cancer. 2004 Mar;12(3):197-201. doi: 10.1007/s00520-003-0576-z. Epub 2004 Jan 16.
To evaluate the characteristics of implantable venous port-related infections in patients with malignancies.
This was a 6-year study in which all the records of cancer patients who were diagnosed with port-related infections were retrospectively analyzed.
The analysis included 36 episodes of port-related infections. The median period from port implantation to the episode of port-related infection was 164 days (21 to 1650 days). Of the 36 episodes, 15 (42%) were polymicrobial infections, and 21 (58%) were gram-negative pathogens. If only the port-related bacteremia was taken into consideration, gram-negative bacilli and gram-positive cocci accounted for 39 and 7 pathogens of the total 53 isolated microorganisms (74% and 13%, respectively). Stenotrophomonas maltophilia and Acinetobacter baumanii were the predominant causal microorganisms. All except two infectious catheters were removed. No infection-related mortality developed.
Gram-negative bacilli, especially the glucose-non-fermenting pathogens, tend to be the major microorganisms that account for port-related infections, and the infections run a benign course, even those developed in septicemia.
评估恶性肿瘤患者中可植入式静脉端口相关感染的特征。
这是一项为期6年的研究，对所有被诊断为端口相关感染的癌症患者记录进行回顾性分析。
分析包括36例端口相关感染病例。从端口植入到发生端口相关感染的中位时间为164天（21至1650天）。在这36例病例中，15例（42%）为多微生物感染，21例（58%）为革兰氏阴性病原体感染。若仅考虑端口相关菌血症，革兰氏阴性杆菌和革兰氏阳性球菌分别占分离出的53种微生物中的39种和7种（分别占74%和13%）。嗜麦芽窄食单胞菌和鲍曼不动杆菌是主要致病微生物。除两根感染导管外，其余均被移除。未发生与感染相关的死亡。
革兰氏阴性杆菌，尤其是非发酵葡萄糖病原体，往往是导致端口相关感染的主要微生物，且感染病程呈良性，即使是败血症相关感染。
