Ku S C, Hsueh P R, Yang P C, Luh K T
Department of Internal Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei.
Eur J Clin Microbiol Infect Dis. 2000 Jul;19(7):501-5. doi: 10.1007/s100960000315.
A retrospective study was conducted to analyze the clinical features and pathogenic roles of bacteremia caused by Acinetobacter lwoffii during a 4-year period. Acinetobacter lwoffii (formerly Acinetobacter calcoaceticus var. lwoffii) is recognized as normal flora of the skin, oropharynx and perineum of healthy individuals. There are few reports of Acinetobacter lwoffii bacteremia associated with indwelling catheters in humans, particularly in immunocompromised hosts. The records of 18 patients with Acinetobacter lwoffii bacteremia whose underlying conditions included cancer (11 patients), systemic lupus erythematosus (n=1), chronic obstructive pulmonary disease (n = 2) and other diseases (n = 4), all but one of whom had indwelling catheters during the bacteremic episode, were examined. The clinical syndromes were classified as probable catheter-related bacteremia (n = 14), definite catheter-related bacteremia (n = 2), primary bacteremia (n = 1) or biliary tract infection (n = 1). The infections improved after removal of the catheter and/or appropriate antimicrobial therapy. One death was attributable to the bacteremic event. The results of this study show that indwelling catheter-related Acinetobacter lwoffii bacteremia in immunocompromised hosts appears to be associated with a low risk of mortality.
进行了一项回顾性研究，以分析四年期间鲁氏不动杆菌引起的菌血症的临床特征和致病作用。鲁氏不动杆菌（以前称为醋酸钙不动杆菌鲁氏变种）被认为是健康个体皮肤、口咽和会阴的正常菌群。关于鲁氏不动杆菌菌血症与人类留置导管相关的报道很少，尤其是在免疫功能低下的宿主中。检查了18例鲁氏不动杆菌菌血症患者的记录，其基础疾病包括癌症（11例）、系统性红斑狼疮（n = 1）、慢性阻塞性肺疾病（n = 2）和其他疾病（n = 4），除1例患者外，所有患者在菌血症发作期间均有留置导管。临床综合征分为可能的导管相关菌血症（n = 14）、明确的导管相关菌血症（n = 2）、原发性菌血症（n = 1）或胆道感染（n = 1）。去除导管和/或进行适当的抗菌治疗后，感染有所改善。1例死亡归因于菌血症事件。本研究结果表明，免疫功能低下宿主中与留置导管相关的鲁氏不动杆菌菌血症似乎与低死亡率风险相关。
