Santos M Lurdes, Mota-Miranda António, Alves-Pereira António, Gomes Armanda, Correia José, Marçal Nelson
Infectious Diseases Service-Intensive Care Unit, Hospital S. João and School of Medicine, Porto, Portugal.
Clin Infect Dis. 2004 Feb 1;38(3):321-8. doi: 10.1086/380636. Epub 2004 Jan 7.
Tetanus remains a serious problem in public health, particularly in developing countries, despite efficient prevention programs. A retrospective study was conducted at an infectious diseases intensive care unit during 1998-2003 involving patients admitted with grade III tetanus. The aim of the study was to evaluate the efficacy and safety of intrathecal baclofen for the treatment of tetanus. Lumbar puncture was performed, and a subarachnoid catheter was inserted for drug administration. An intrathecal bolus of baclofen was followed by a continuous infusion of 20 microg/h, until a maximum daily dose of 2 mg was provided. Twenty-two patients were treated overall. Control of the symptoms was achieved in all patients but one. Seven patients had colonization of the catheter, and 1 patient developed meningitis. All patients except one recovered. In our study, this means of treatment was efficacious and well tolerated.
尽管有有效的预防计划，但破伤风在公共卫生领域仍是一个严重问题，在发展中国家尤为如此。1998年至2003年期间，在一家传染病重症监护病房对III级破伤风患者进行了一项回顾性研究。该研究的目的是评估鞘内注射巴氯芬治疗破伤风的疗效和安全性。进行了腰椎穿刺，并插入蛛网膜下腔导管用于给药。先鞘内注射一次巴氯芬，然后以20微克/小时的速度持续输注，直至每日最大剂量达到2毫克。总共治疗了22名患者。除1名患者外，所有患者的症状均得到控制。7名患者出现导管定植，1名患者发生脑膜炎。除1名患者外，所有患者均康复。在我们的研究中，这种治疗方法有效且耐受性良好。
