吉兰-巴雷综合征和米勒-费雪综合征中的迟发性面部无力。
Delayed facial weakness in Guillain-Barré and Miller Fisher syndromes.
作者信息
Tatsumoto Muneto, Misawa Sonoko, Kokubun Norito, Sekiguchi Yukari, Hirata Koichi, Kuwabara Satoshi, Yuki Nobuhiro
机构信息
Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
出版信息
Muscle Nerve. 2015 Jun;51(6):811-4. doi: 10.1002/mus.24475. Epub 2015 Jan 9.
INTRODUCTION
Dr. C. Miller Fisher described the appearance of unilateral facial palsy after resolution of ataxia in a patient with the eponymic Miller Fisher syndrome (MFS). However, there have been very few reports of delayed appearance of facial weakness in Guillain-Barré syndrome (GBS) and MFS when the other neurological signs reached nadir or started improving.
METHODS
In this study we reviewed the clinical and laboratory findings of consecutive patients with GBS (n=195) and MFS (n=68).
RESULTS
Delayed facial weakness occurred in 12 (6%) GBS and 4 (6%) MFS patients and was unilateral in 5 (42%) GBS and 2 (50%) MFS patients. In those patients with delayed facial weakness, neither limb weakness nor ataxia progressed, and facial weakness disappeared without immunotherapy.
CONCLUSIONS
Because facial weakness can lead to further morbidity, it would be prudent for clinicians to warn patients of this possibility, although additional immunotherapy is usually not required.
引言
C. 米勒·费舍尔医生描述了以其名字命名的米勒·费舍尔综合征（MFS）患者共济失调缓解后出现单侧面瘫的情况。然而，关于吉兰 - 巴雷综合征（GBS）和MFS在其他神经体征达到最低点或开始改善时出现延迟性面部无力的报道非常少。
方法
在本研究中，我们回顾了连续的GBS患者（n = 195）和MFS患者（n = 68）的临床和实验室检查结果。
结果
12例（6%）GBS患者和4例（6%）MFS患者出现延迟性面部无力，其中5例（42%）GBS患者和2例（50%）MFS患者为单侧面部无力。在这些出现延迟性面部无力的患者中，肢体无力和共济失调均未进展，且未经免疫治疗面部无力就消失了。
结论
由于面部无力可能导致进一步的发病情况，尽管通常不需要额外的免疫治疗，但临床医生告知患者这种可能性是谨慎的做法。
Zotero 插件