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添加剂对模型蛋白从聚乳酸-羟基乙酸共聚物微球中释放的影响。

Effect of additives on the release of a model protein from PLGA microspheres.

作者信息

Kang F, Singh J

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND 58105, USA.

出版信息

AAPS PharmSciTech. 2001 Dec 17;2(4):30. doi: 10.1208/pt020430.

DOI:10.1208/pt020430
PMID:14727867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2784845/
Abstract

The purpose of this study was to investigate the effect of 2 additives, poly(ethylene glycol) (PEG) 1000 and 1,2,3-tridecanoyl glycerol (tricaprin), on the physico-chemical characteristics and in vitro release of a model protein, bovine serum albumin (BSA), form poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres. BSA-loaded microspheres were prepared by the double emulsion solvent evaporation method. Additives were incorporated into microspheres to modify the release of protein. The addition of PEG 1000 and tricaprin changed the surface characteristics of microspheres from smooth and nonporous to porous and dimpled, respectively. The in vitro release profiles showed that the additives significantly (P < 0.05) increased the early-stage release of BSA from microspheres.

摘要

本研究的目的是研究两种添加剂，聚乙二醇（PEG）1000和1,2,3-三癸酰甘油（三癸精），对聚（D，L-乳酸-共-乙醇酸）（PLGA）微球中模型蛋白牛血清白蛋白（BSA）的物理化学特性和体外释放的影响。通过复乳溶剂蒸发法制备了载BSA的微球。将添加剂加入微球中以改变蛋白质的释放。PEG 1000和三癸精的加入分别使微球的表面特性从光滑无孔变为多孔有凹痕。体外释放曲线表明，添加剂显著（P < 0.05）增加了微球中BSA的早期释放。

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