Wetherell Julie Loebach, Palmer Barton W, Thorp Steven R, Patterson Thomas L, Golshan Shahrokh, Jeste Dilip V
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0603, USA.
J Clin Psychiatry. 2003 Dec;64(12):1476-82. doi: 10.4088/jcp.v64n1212.
This study examined whether anxiety symptoms make an independent contribution to poorer quality of life among middle-aged and older outpatients with schizophrenia or schizoaffective disorder.
We evaluated data from an ongoing study of 163 older patients with DSM-III-R or DSM-IV schizophrenia or schizoaffective disorder who were enrolled in research at the University of California, San Diego, Advanced Center for Interventions and Services Research from October 1992 to April 1998. Measures used were the anxiety, somatization, obsessive-compulsive, and phobic anxiety subscales of the Brief Symptom Inventory. We performed hierarchical multiple regressions with forced entry of variables to determine whether anxiety symptoms significantly predicted poorer health-related quality of life (measured by 2 scales) after controlling for demographic variables, akathisia, cognitive impairment, depressive symptoms, and overall psychopathology.
Anxiety symptoms were associated with poorer outcomes on overall quality of well-being and subscales representing vitality, social functioning, and role functioning limitations due to physical problems. In most cases, the proportion of variance in quality of life accounted for by anxiety symptoms was greater than that accounted for by depressive symptoms.
Results suggest that anxiety symptoms have a significant negative impact on the quality of life of middle-aged and older patients with schizophrenia and schizoaffective disorder.
本研究探讨焦虑症状是否对中年及老年精神分裂症或分裂情感性障碍门诊患者较差的生活质量有独立影响。
我们评估了一项正在进行的研究的数据，该研究纳入了163名患有DSM-III-R或DSM-IV精神分裂症或分裂情感性障碍的老年患者，他们于1992年10月至1998年4月在加利福尼亚大学圣地亚哥分校高级干预与服务研究中心参与研究。使用的测量工具为简明症状量表中的焦虑、躯体化、强迫观念及恐惧焦虑分量表。我们进行了分层多元回归分析，强制纳入变量以确定在控制人口统计学变量、静坐不能、认知障碍、抑郁症状及总体精神病理学因素后，焦虑症状是否能显著预测较差的健康相关生活质量（通过两个量表测量）。
焦虑症状与总体幸福感较差以及代表活力、社会功能和因身体问题导致的角色功能受限的分量表得分较低相关。在大多数情况下，焦虑症状对生活质量变异的解释比例大于抑郁症状。
结果表明，焦虑症状对中年及老年精神分裂症和分裂情感性障碍患者的生活质量有显著负面影响。
