Atzmon Gil, Schechter Clyde, Greiner William, Davidson Deborah, Rennert Gad, Barzilai Nir
Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
J Am Geriatr Soc. 2004 Feb;52(2):274-7. doi: 10.1111/j.1532-5415.2004.52068.x.
To determine whether offspring of centenarians acquired protection from age-related diseases.
Case-control study.
The study was part of the Longevity Genes Project at Albert Einstein College of Medicine.
Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey.
Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass.
Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) "risk" for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups.
Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment.
确定百岁老人的后代是否获得了对与年龄相关疾病的保护。
病例对照研究。
该研究是阿尔伯特·爱因斯坦医学院长寿基因项目的一部分。
百岁老人（n = 145）、百岁老人的后代（n = 180）以及百岁老人后代的配偶（n = 75）作为对照组。另外两组作为对照：年龄匹配的德系犹太人，以及来自第三次全国健康与营养检查调查的年龄匹配对照组。
自我报告的长寿家族史；高血压、糖尿病、心脏病发作和中风的患病率；以及体重指数和脂肪量的客观测量。
百岁老人的父母（出生于约1870年）拥有显著更高（约七倍）的活到90 - 99岁的“风险”，支持了遗传学在这些家族的长寿中起作用这一观点。与几个年龄匹配的对照组相比，长寿父母的后代患高血压（降低23%）、糖尿病（降低50%）、心脏病发作（降低60%）和中风（无病例报告）的患病率显著更低。
百岁老人的后代可能继承了明显更好的健康状况。作者建议对这些受试者及其配偶进行队列研究，以研究长寿的表型和基因型及其与环境的相互作用。
