Barzilai N, Gabriely I, Gabriely M, Iankowitz N, Sorkin J D
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
J Am Geriatr Soc. 2001 Jan;49(1):76-9. doi: 10.1046/j.1532-5415.2001.49013.x.
It is well recognized that a favorable lipid profile provides protection from atherosclerotic cardiovascular disease. Because the major cause of nontraumatic death in the western world is considered to be due to cardiovascular disease, centenarians (defined here as subjects over 95 years of age) are believed to possess "atherosclerotic protective" factors. However, it is impossible to study comparatively the lipid profile in centenarians because of lack of controls. Assuming that certain genes responsible for encoding the lipid phenotype may be inherited, we studied the lipid profile characteristics of offspring of centenarians and compared them with control groups.
Prospective cohort study.
The study was part of the Longevity Genes Project at Albert Einstein College of Medicine.
Ashkenazi Jewish centenarians (n = 27, 98.4 +/- 10.4 years) and their offspring (n = 33, 67.4 +/- 1.4 years). The Ashkenazi Jewish offsprings' spouses, who were not related by blood to the centenarians or their offspring, were used as a control group (n = 26, 68.4 +/- 1.2 years).
The lipoprotein profile of the offspring was compared with the above control group and to a larger control group (age and gender matched) from the National Health and Nutrition Examination Survey (NHANES) III study (without the sample weights, n = 394, 60 to 69 years).
Female offspring of centenarians had significantly higher plasma levels of high density lipoprotein-cholesterol (HDL-C) levels compared with controls (70.2 +/- 3.1 vs 59.0 +/- 4.1 mg/dl, P = .029). Male offspring of centenarians had higher plasma levels of HDL-C levels (56.2 +/- 7.1 vs 44.3 +/- 3.4 mg/dl, P = 0.130) and significantly lower LDL-cholesterol (LDL-C) levels (95.0 +/- 6.0 vs 127.0 +/- 8.0 mg/dl, P = .009) compared with controls.
Offspring of centenarians have a favorable lipid profile compared with controls. These data support the notion that a certain phenotypic lipid profile may be transmitted in families and suggest that a favorable lipid profile may play a role in longevity.
众所周知，良好的血脂谱可预防动脉粥样硬化性心血管疾病。由于西方世界非创伤性死亡的主要原因被认为是心血管疾病，因此人们认为百岁老人（此处定义为95岁以上的人群）拥有“抗动脉粥样硬化”因素。然而，由于缺乏对照组，无法对百岁老人的血脂谱进行比较研究。假设某些负责编码脂质表型的基因可能是可遗传的，我们研究了百岁老人后代的血脂谱特征，并将其与对照组进行比较。
前瞻性队列研究。
该研究是阿尔伯特爱因斯坦医学院长寿基因项目的一部分。
阿什肯纳兹犹太百岁老人（n = 27，98.4±10.4岁）及其后代（n = 33，67.4±1.4岁）。阿什肯纳兹犹太后代的配偶与百岁老人或其后代无血缘关系，用作对照组（n = 26，68.4±1.2岁）。
将后代的脂蛋白谱与上述对照组以及来自国家健康和营养检查调查（NHANES）III研究的更大对照组（年龄和性别匹配）（无样本权重，n = 394，60至69岁）进行比较。
与对照组相比，百岁老人的女性后代血浆高密度脂蛋白胆固醇（HDL-C）水平显著更高（70.2±3.1对59.0±4.1mg/dl，P = 0.029）。与对照组相比，百岁老人的男性后代HDL-C水平更高（56.2±7.1对44.3±3.4mg/dl，P = 0.130），低密度脂蛋白胆固醇（LDL-C）水平显著更低（95.0±6.0对127.0±8.0mg/dl，P = 0.009）。
与对照组相比，百岁老人的后代具有良好的血脂谱。这些数据支持了某种表型血脂谱可能在家族中传递的观点，并表明良好的血脂谱可能在长寿中起作用。
