Subramanyan Kumar
Unilever Global Skin Innovation Center, 40 Merritt Boulevard, Trumbull, Connecticut 06611, USA.
Dermatol Ther. 2004;17 Suppl 1:26-34. doi: 10.1111/j.1396-0296.2004.04s1003.x.
Routine everyday care of skin is an essential part of optimal patient management. Common problems such as xerosis, dermatitis, eczema, psoriasis, acne, rosacea, and photodamage leave the skin vulnerable to external insults, partly as a result of varying levels of barrier dysfunction. Cosmetic surgery procedures also typically damage the stratum corneum (SC) and leave skin with a very weak barrier during recovery phase. Cleansing is an important aspect of any skin care, since it not only removes unwanted dirt, soil, and bacteria from skin, but also removes dead surface cells, preparing skin to better absorb topically applied drugs/medication. Care must be taken to minimize any further weakening of the SC barrier during cleansing. Cleansers based on mild synthetic surfactants and/or emollients that cause minimal barrier perturbation are ideal for these patients. The present paper is a brief review of four clinical trials that evaluated the efficacy and compatibility of either mild syndet bars or cleansers in patients with atopic dermatitis, acne, rosacea, or patients who had received chemical peels or Retin-A(R) (tretinoin) treatment for sustained photodamage.
日常皮肤护理是优化患者管理的重要组成部分。诸如皮肤干燥、皮炎、湿疹、银屑病、痤疮、酒渣鼻和光损伤等常见问题会使皮肤容易受到外部侵害，部分原因是屏障功能存在不同程度的障碍。整容手术通常也会损伤角质层（SC），并在恢复阶段使皮肤屏障非常薄弱。清洁是任何皮肤护理的重要方面，因为它不仅能去除皮肤表面不需要的污垢、灰尘和细菌，还能去除死亡的表层细胞，使皮肤更好地吸收局部应用的药物。在清洁过程中必须注意尽量减少对角质层屏障的进一步削弱。基于温和合成表面活性剂和/或润肤剂且对角质层屏障扰动最小的洁面产品对这些患者来说是理想之选。本文简要综述了四项临床试验，这些试验评估了温和合成清洁剂或洁面产品在特应性皮炎、痤疮、酒渣鼻患者，或接受化学换肤或维甲酸（维甲酸）治疗以改善持续性光损伤的患者中的疗效和兼容性。
