Specialist Skin Clinic, Singapore.
Am J Clin Dermatol. 2009;10 Suppl 1:13-7. doi: 10.2165/0128071-200910001-00003.
Atopic dermatitis is a common condition characterized by pruritus, inflammation, and dryness of the skin. Inflammation disrupts the barrier function of the stratum corneum, predisposing the skin to be dry, and increases susceptibility to irritants and secondary bacterial infection. Sensitive skin is common, reported by 40-50% of women and 30% of men in the US, Europe, and Japan. Basic requirements in managing eczema and sensitive skin include effective cleansers that do not compromise skin barrier integrity, alleviation of skin dryness, and restoration of skin barrier function through the use of therapeutic moisturizers. The selection of a skin cleanser is therefore an important part of managing these conditions. Studies have reported clinical improvement with the use of soap-free cleansers in combination with topical treatments. While topical corticosteroids and immunosuppressive agents are mainstays of treatment for atopic dermatitis, therapeutic moisturizers are important adjuncts. Moisturizers improve skin hydration, reduce susceptibility to irritation, restore the integrity of the stratum corneum, and enhance the efficacy of topical corticosteroids.
特应性皮炎是一种常见的疾病，其特征为瘙痒、炎症和皮肤干燥。炎症会破坏角质层的屏障功能，使皮肤容易干燥，并增加对刺激物和继发性细菌感染的敏感性。敏感性皮肤很常见，据报道，在美国、欧洲和日本，40-50%的女性和 30%的男性有这种皮肤。管理特应性皮炎和敏感性皮肤的基本要求包括：不会损害皮肤屏障完整性的有效清洁剂、缓解皮肤干燥以及通过使用治疗性保湿剂恢复皮肤屏障功能。因此，选择皮肤清洁剂是管理这些疾病的重要组成部分。研究报告称，在联合使用无皂清洁剂和局部治疗的情况下，临床症状有改善。虽然局部皮质类固醇和免疫抑制剂是特应性皮炎治疗的基础，但治疗性保湿剂也是重要的辅助治疗。保湿剂可改善皮肤的水合作用、降低皮肤对刺激物的敏感性、恢复角质层的完整性，并增强局部皮质类固醇的疗效。
