Claustrat B, Brun J, Chiquet C, Chazot G, Borson-Chazot F
Service de Radioanalyse, Hôpital Neuro-Cardiologique, Institut Fédératif de Neurosciences, Lyon, France.
Cephalalgia. 2004 Feb;24(2):128-33. doi: 10.1111/j.1468-2982.2004.00645.x.
The present study examined the sensitivity to light of melatonin (MLT) secretion in familial migraine during a headache-free interval. Twelve female patients and 12 healthy controls were included in the trial. All subjects were studied twice. In each session, light exposure (300 lx) or placebo was randomly administered for 30 min between 00.30 and 01.00 h. Blood was sampled hourly between 20.00 and 24.00 h, and 02.00 and 04.00 h and every 15 min between 00.30 and 01.30 h. Plasma MLT levels were determined by radioimmunoassay. MLT suppression was more marked in the migraine group than in the control group [difference of area under curve (DeltaAUC)=-53.8 +/- 16.2 vs. 18.5 +/- 12.7 pg/h/ml, P<0.005; maximum of MLT suppression (Delta)=-35.7 +/- 10.2 vs. - 6.7 +/- 5.8 pg/ml, P<0.05]. These findings show a clear hypersensitivity to light in young female migraineurs during the headache-free period.
本研究在无头痛间歇期检测了家族性偏头痛患者褪黑素（MLT）分泌对光的敏感性。12名女性患者和12名健康对照者纳入试验。所有受试者均进行了两次研究。在每次研究中，于00:30至01:00之间随机给予30分钟的光照（300勒克斯）或安慰剂。在20:00至24:00、02:00至04:00每小时采血一次，在00:30至01:30每15分钟采血一次。采用放射免疫分析法测定血浆MLT水平。偏头痛组的MLT抑制比对照组更明显[曲线下面积差异（DeltaAUC）=-53.8±16.2对18.5±12.7 pg/h/ml，P<0.005；MLT抑制最大值（Delta）=-35.7±10.2对-6.7±5.8 pg/ml，P<0.05]。这些发现表明，年轻女性偏头痛患者在无头痛期对光存在明显的超敏反应。
