假设的高胆固醇血症与动脉粥样硬化。
Hypothetical hypercholesterolaemia and atherosclerosis.
作者信息
Stehbens W E
机构信息
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, PO Box 7343, Wellington South, Wellington, New Zealand.
出版信息
Med Hypotheses. 2004;62(1):72-8. doi: 10.1016/s0306-9877(03)00267-6.
Recent pathological advances in experimental and iatrogenic atherosclerosis and critical review of the epidemiology of coronary heart disease revealed fallacious data and methodological errors underlying the hypercholesterolaemia/lipid hypothesis. Misuse of risk factors, inappropriate use of surrogates and misinterpretation of data pertaining to cholesterol's role in atherogenesis necessitate greater precision in word usage and terminology, reinstitution of the statistical reference range for cholesterol and closer scientific surveillance of aetiological endeavours in medicine.
实验性和医源性动脉粥样硬化的最新病理学进展以及对冠心病流行病学的批判性综述揭示了高胆固醇血症/脂质假说背后存在错误数据和方法学错误。对风险因素的滥用、替代指标的不当使用以及对胆固醇在动脉粥样硬化形成中作用的数据误解，都需要在词汇使用和术语上更加精确，重新确立胆固醇的统计参考范围，并加强对医学病因学研究的科学监督。
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