Lahaye Thomas
Institute of Genetics, Martin-Luther-Universität Halle-Wittenberg, 06099 (Saale), Halle, Germany.
Trends Plant Sci. 2004 Jan;9(1):1-4. doi: 10.1016/j.tplants.2003.11.002.
Elucidation of the molecular basis of gene-for-gene interactions between disease-resistance (R) genes and pathogen avirulence (avr) genes has been a Holy Grail of plant pathology for the past decade. Recent studies of the R-avr interaction between RRS1-R and popP2 by Laurent Deslandes et al. provide new insights and suggest a direct physical association of the encoded proteins in support of a simplistic receptor-ligand model. However, careful consideration of the experimental findings reveals that they could also be explained by molecular linker proteins that mediate formation of a PopP2 and RRS1-R uniting complex.
在过去十年中，阐明抗病（R）基因与病原体无毒（avr）基因之间基因对基因相互作用的分子基础一直是植物病理学的圣杯。洛朗·德斯兰德斯等人最近对RRS1-R和popP2之间的R-avr相互作用进行的研究提供了新的见解，并表明编码蛋白存在直接的物理关联，以支持一个简单的受体-配体模型。然而，仔细考虑实验结果会发现，它们也可以用介导PopP2和RRS1-R结合复合物形成的分子连接蛋白来解释。
