大鼠制动应激后快速眼动睡眠发作的模式。

Pattern of rapid-eye movement sleep episode occurrence after an immobilization stress in the rat.

作者信息

Dewasmes G, Loos N, Delanaud S, Dewasmes D, Ramadan W

机构信息

University of Picardie J. Verne, School of Medicine of Amiens, ETP-APC, 3 rue des Louvels, 80036 Amiens Cedex, France.

出版信息

Neurosci Lett. 2004 Jan 23;355(1-2):17-20. doi: 10.1016/j.neulet.2003.10.031.

DOI:10.1016/j.neulet.2003.10.031

PMID:14729224

Abstract

Rapid-eye movement sleep (REMS) in the rat occurs in the form of episodes separated by long (>3 min: isolated REMS episodes, IREMSEs) and short (<3 min: sequential REMS episodes, SREMSEs) intervals. The mechanism clustering SREMSEs is thought to be better suited to increase the amount of REMS when its drive is high. We tested this hypothesis in a new situation by transiently augmenting this drive with a moderate psychogenic stress. After a 90-min immobilization stress, REMS increased by 54% over the rest of the dark phase. This increase was associated with a modest increase in IREMSEs (+40%), but a massive increase in SREMSEs (+300%). Thus, the mechanism that clusters REMS episodes operates in response to a moderate psychogenic stress imposed in standard laboratory conditions and not preceded by sleep deprivation.

摘要

大鼠的快速眼动睡眠（REMS）以发作形式出现，发作之间间隔时长不等（长于3分钟：孤立快速眼动睡眠发作，IREMSEs；短于3分钟：连续快速眼动睡眠发作，SREMSEs）。当快速眼动睡眠驱动力较高时，聚集连续快速眼动睡眠发作的机制被认为更适合增加快速眼动睡眠量。我们在一种新的情境中通过适度的心理应激短暂增强这种驱动力来检验这一假设。在90分钟的固定应激后，快速眼动睡眠在黑暗期剩余时间内增加了54%。这种增加与孤立快速眼动睡眠发作适度增加（+40%）相关，但连续快速眼动睡眠发作大幅增加（+300%）。因此，聚集快速眼动睡眠发作的机制是在标准实验室条件下施加适度心理应激且无睡眠剥夺先行的情况下做出反应的。