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HTTM, a horizontally transferred transmembrane domain.

作者信息

Schultz Jörg

机构信息

Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany.

出版信息

Trends Biochem Sci. 2004 Jan;29(1):4-7. doi: 10.1016/j.tibs.2003.11.002.

DOI:10.1016/j.tibs.2003.11.002
PMID:14729325
Abstract

Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is probably caused by horizontal gene transfer rather than by early evolution. The conservation of VKGC catalytic sites also indicates an enzymatic function for the other family members.

摘要

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