Cohen-Gonsaud Martin, Keep Nicholas H, Davies Angharad P, Ward John, Henderson Brian, Labesse Gilles
School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK.
Trends Biochem Sci. 2004 Jan;29(1):7-10. doi: 10.1016/j.tibs.2003.10.009.
The novel bacterial cytokine family--resuscitation-promoting factors (Rpfs)--share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.
新型细菌细胞因子家族——复苏促进因子（Rpfs）——共享一个功能未知的保守结构域。对该结构域结构的预测表明，Rpfs具有一个类似溶菌酶的结构域。该模型突出了参与催化和底物结合的残基的良好保守性。鉴于Rpfs生物学功能的实验表征，类似溶菌酶的功能对于该结构域来说是合理的。
