Padilla C, Lobos O, Brevis P, Abaca P, Hubert E
Laboratorio de Investigación Microbiológica and Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Talca, Chile.
J Antimicrob Chemother. 2004 Feb;53(2):390-2. doi: 10.1093/jac/dkh067. Epub 2004 Jan 16.
To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples.
The qualitative disc diffusion method and MIC determinations were used.
The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis.
There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.
分析肽PsVP - 10对从临床样本中分离出的67株耐粪肠球菌菌株的抗菌活性。
采用定性纸片扩散法和最低抑菌浓度测定法。
证实了粪肠球菌存在多种多重耐药表型，其中对氯霉素、四环素、万古霉素、头孢菌素、氨苄青霉素和庆大霉素的最低抑菌浓度较高。相比之下，肽PsVP - 10对所有多重耐药和敏感的粪肠球菌的最低抑菌浓度较低。
迫切需要开发针对高度耐药粪肠球菌的新型抗菌剂。本研究表明，肽PsVP - 10可能有助于解决这一严重问题。
