多发性硬化症患者的皮肤癌：一项记录链接研究。
Skin cancer in people with multiple sclerosis: a record linkage study.
作者信息
Goldacre M J, Seagroatt V, Yeates D, Acheson E D
机构信息
Unit of Health-Care Epidemiology, Department of Public Health, Institute of Health Sciences, Oxford University, Oxford, UK.
出版信息
J Epidemiol Community Health. 2004 Feb;58(2):142-4. doi: 10.1136/jech.58.2.142.
OBJECTIVE
The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others.
DESIGN
Analysis of a database of linked hospital records and death certificates.
SETTING
The Oxford Region of the National Health Service, England.
SUBJECTS
A cohort comprising all people in the database with MS, and comparison cohorts of people with other diseases.
RESULTS
Skin cancer was significantly less common in people with MS than in the main comparison cohort (rate ratio 0.49; 95% confidence interval 0.24 to 0.91). There was no general deficit of cancer in the MS cohort, and no deficit of skin cancer in cohorts of people with other autoimmune or neurological diseases.
CONCLUSION
The findings support the hypothesis that solar radiation may have a protective influence on the development of MS.
目的
多发性硬化症（MS）的患病率随纬度变化：在两个半球均随与赤道距离的增加而上升。为寻找太阳辐射是否为MS保护因素的证据，本研究调查作为太阳辐射指标的皮肤癌在MS患者中是否比其他人更不常见。
设计
对关联的医院记录和死亡证明数据库进行分析。
地点
英国国家医疗服务体系牛津地区。
研究对象
一个由数据库中所有MS患者组成的队列，以及患有其他疾病的对照队列。
结果
MS患者患皮肤癌的情况显著少于主要对照队列（率比0.49；95%置信区间0.24至0.91）。MS队列中不存在普遍的癌症不足情况，在患有其他自身免疫性或神经系统疾病的队列中也不存在皮肤癌不足情况。
结论
研究结果支持太阳辐射可能对MS发病具有保护作用这一假说。
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