Nienhuis H, Goldacre M, Seagroatt V, Gill L, Vessey M
Unit of Clinical Epidemiology, University of Oxford.
BMJ. 1992 Mar 21;304(6829):743-6. doi: 10.1136/bmj.304.6829.743.
To determine whether vasectomy is associated with an increased risk of several diseases, and in particular testicular cancer, after operation.
Retrospective cohort study using linked medical record abstracts.
Six health districts in Oxford region.
13,246 men aged 25-49 years who had undergone vasectomy between 1970 and 1986, and 22,196 comparison subjects who had been admitted during the same period for one of three specified elective operations, appendicitis, or injuries.
Hospital admission and death after vasectomy or comparison event.
The mean durations of follow up were 6.6 years for men with a vasectomy and 7.5 years for men with a comparison condition. The relative risk of cancer of the testis in the vasectomy cohort (4 cases) compared with that in the other cohorts (17 cases) was 0.46 (95% confidence interval 0.1 to 1.4), that of cancer of the prostate (1 v 5 cases) 0.44 (0.1 to 4.0), and that of myocardial infarction (97 v 226 cases) 1.00 (0.8 to 1.3). There was no evidence of an increase associated with vasectomy in the incidence of a range of other diseases.
Vasectomy was not associated with an increased risk of testicular cancer or the other diseases studied. With respect to prostatic cancer, while we found no cause for concern, longer periods of observation on large numbers of men are required.
确定输精管结扎术后是否会增加患几种疾病的风险，尤其是睾丸癌。
使用关联医疗记录摘要的回顾性队列研究。
牛津地区的六个健康区。
1970年至1986年间接受输精管结扎术的13246名年龄在25至49岁之间的男性，以及同期因三种特定择期手术、阑尾炎或受伤之一入院的22196名对照对象。
输精管结扎术或对照事件后的住院和死亡情况。
输精管结扎术男性的平均随访时间为6.6年，对照情况男性为7.5年。输精管结扎术队列中睾丸癌（4例）与其他队列（17例）相比的相对风险为0.46（95%置信区间0.1至1.4），前列腺癌（1例对5例）为0.44（0.1至4.0），心肌梗死（97例对226例）为1.00（0.8至1.3）。没有证据表明输精管结扎术会增加一系列其他疾病的发病率。
输精管结扎术与睾丸癌或其他所研究疾病的风险增加无关。关于前列腺癌，虽然我们没有发现令人担忧的原因，但需要对大量男性进行更长时间的观察。
