Ragozzino M E, Parker M E, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903.
Brain Res. 1992 Dec 4;597(2):241-9. doi: 10.1016/0006-8993(92)91480-3.
Peripheral glucose administration attenuates impairments produced by peripheral injections of the opioid agonist, morphine, on spontaneous alternation. Injections of opioid agonists directly into the medial septum also impair memory. The present experiments examined whether systemic and intraseptal glucose injections could attenuate deficits on spontaneous alternation and inhibitory avoidance in rats treated with intraseptal morphine. Morphine (3.95 nmol) injected into the medial septum significantly impaired performance on spontaneous alternation and inhibitory avoidance tasks. Both systemic (100 mg/kg, i.p.) and intraseptal (18.33 nmol) injections of glucose, administered concomitantly with intraseptal morphine, attenuated the morphine-induced impairments on these tasks in rats. These findings suggest that one brain region where glucose may act is the medial septum, possibly by releasing opioid inhibition of cholinergic activity.
外周给予葡萄糖可减轻外周注射阿片类激动剂吗啡对自发交替行为产生的损害。直接向内侧隔区注射阿片类激动剂也会损害记忆。本实验研究了全身性和隔区内注射葡萄糖是否能减轻隔区内注射吗啡的大鼠在自发交替行为和抑制性回避方面的缺陷。向内侧隔区注射吗啡（3.95纳摩尔）显著损害了自发交替行为和抑制性回避任务的表现。与隔区内注射吗啡同时给予全身性（100毫克/千克，腹腔注射）和隔区内（18.33纳摩尔）葡萄糖注射，可减轻吗啡对大鼠这些任务的诱导性损害。这些发现表明，葡萄糖可能发挥作用的一个脑区是内侧隔区，可能是通过解除阿片类物质对胆碱能活性的抑制来实现的。
