Ragozzino M E, Hellems K, Lennartz R C, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903, USA.
Behav Neurosci. 1995 Dec;109(6):1074-80. doi: 10.1037//0735-7044.109.6.1074.
Glucose infusions into the medial septal area attenuate memory impairments produced by concurrent intraseptal morphine injections. One possible explanation for these effects of glucose on memory is that the treatment modulates regional energy metabolism. As a test of this hypothesis, the present experiment determined whether intraseptal pyruvate injections could attenuate a spontaneous alternation impairment seen after intraseptal morphine injections. Intraseptal injections of morphine (4.0 nmol) 30 min prior to testing produced spontaneous alternation scores significantly lower than those in control groups. Morphine injections near, but outside, the septal region did not impair spontaneous alternation performance. The morphine-induced impairment was similarly reversed by coadministration of either glucose (18 nmol) or pyruvate (18 nmol) into the septum. These findings suggest that glucose may act through the tricarboxylic acid cycle by increasing the availability of ATP, augmenting the synthesis of certain neurotransmitters, or both.
向内侧隔区输注葡萄糖可减轻同时进行的隔区内注射吗啡所产生的记忆损伤。葡萄糖对记忆产生这些作用的一种可能解释是，该治疗调节了局部能量代谢。作为对这一假设的检验，本实验确定隔区内注射丙酮酸是否能减轻隔区内注射吗啡后出现的自发交替损伤。在测试前30分钟隔区内注射吗啡（4.0纳摩尔），其自发交替得分显著低于对照组。在隔区附近但在隔区外注射吗啡并不损害自发交替表现。通过向隔区内共同注射葡萄糖（18纳摩尔）或丙酮酸（18纳摩尔），同样可逆转吗啡诱导的损伤。这些发现表明，葡萄糖可能通过三羧酸循环起作用，增加ATP的可用性，增强某些神经递质的合成，或两者兼而有之。
