Department of Psychology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, USA.
Physiol Behav. 2010 Mar 30;99(4):438-44. doi: 10.1016/j.physbeh.2009.12.002. Epub 2009 Dec 22.
We have found repeatedly that medial septal (MS) infusions of glucose impair memory when co-infused with the gamma-amino butyric acid (GABA) agonist muscimol. The present experiments sought to determine whether the memory-impairing effects of this concentration of glucose would generalize to another GABA(A) receptor agonist and to an agonist from another neurotransmitter system that is known to impair memory. Specifically, we determined whether the dose of glucose that produces memory deficits when combined with muscimol in the MS would also impair memory when co-infused with the GABA(A) receptor modulator chlordiazepoxide (CDP) or the opiate morphine. Male Sprague-Dawley rats were given MS co-infusions and then 15 min later tested for spontaneous alternation or given shock avoidance training (retention tested 48 h later). The results showed that MS infusions of the higher dose of glucose with morphine did not produce memory deficits, whereas, the performance of rats given MS co-infusions of CDP with glucose was impaired. These findings suggest that the memory-impairing effects of brain glucose administration may involve an interaction with the GABA(A) receptor.
我们已经反复发现，当将葡萄糖与γ-氨基丁酸（GABA）激动剂毒蕈碱共注入中隔（MS）时，MS 内的葡萄糖输注会损害记忆。本实验旨在确定这种浓度的葡萄糖对记忆的损害作用是否会推广到另一种 GABA(A)受体激动剂，以及推广到另一种已知会损害记忆的神经递质系统的激动剂。具体来说，我们确定当 MS 中的葡萄糖与毒蕈碱结合使用时会导致记忆缺陷的葡萄糖剂量，当与 GABA(A)受体调节剂氯氮䓬（CDP）或阿片类药物吗啡共输注时是否也会损害记忆。雄性 Sprague-Dawley 大鼠接受 MS 共输注，然后在 15 分钟后进行自发交替测试，或接受回避训练（48 小时后进行保留测试）。结果表明，MS 中高剂量的葡萄糖与吗啡共输注不会产生记忆缺陷，而给予大鼠 CDP 与葡萄糖共输注 MS 会损害其表现。这些发现表明，脑葡萄糖给药的记忆损害作用可能涉及与 GABA(A)受体的相互作用。
