使用全身淋巴照射诱导成年大鼠移植耐受：皮肤、心脏和骨髓同种异体移植的长期存活
Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.
作者信息
Slavin S, Reitz B, Bieber C P, Kaplan H S, Strober S
出版信息
J Exp Med. 1978 Mar 1;147(3):700-7. doi: 10.1084/jem.147.3.700.
Abstract
Lewis rats given total lymphoid irradiation (TLI) accepted bone marrow allografts from AgB-incompatible donors. The chimeras showed no clinical signs of graft-versus-host disease. Skin allografts from the marrow donor strain survived for more than 150 days on the chimeras. However, third-party skin grafts were rejected promptly. Although heart allografts survived more than 300 days in Lewis recipients given TLI and bone marrow allografts, detectable levels of chimerism were not required for permanent survival.
摘要
接受全身淋巴照射（TLI）的Lewis大鼠接受了来自AgB不相合供体的骨髓同种异体移植。嵌合体未表现出移植物抗宿主病的临床症状。来自骨髓供体品系的皮肤同种异体移植在嵌合体上存活超过150天。然而，第三方皮肤移植被迅速排斥。尽管在接受TLI和骨髓同种异体移植的Lewis受体中，心脏同种异体移植存活超过300天，但永久存活并不需要可检测到的嵌合水平。
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