来自链霉菌的抗生素稀疏霉素的化学和生物学特性 - Suppr

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Chemical and biological aspects of sparsomycin, an antibiotic from Streptomyces.

作者信息

Ottenheijm H C, van den Broek L A, Ballesta J P, Zylicz Z

出版信息

Prog Med Chem. 1986;23:219-68. doi: 10.1016/s0079-6468(08)70344-8.

DOI:10.1016/s0079-6468(08)70344-8

PMID:3310108

Abstract

摘要

相似文献

Chemical and biological aspects of sparsomycin, an antibiotic from Streptomyces.来自链霉菌的抗生素稀疏霉素的化学和生物学特性

Prog Med Chem. 1986;23:219-68. doi: 10.1016/s0079-6468(08)70344-8.

Inhibition of protein biosynthesis: the first active sparsomycin analog.

Biochem Biophys Res Commun. 1977 Apr 11;75(3):563-7. doi: 10.1016/0006-291x(77)91509-1.

Sparsomycin analogs. VI. Synthesis and antitumor activity of octylsparsomycin analogs.稀疏霉素类似物。VI。辛基稀疏霉素类似物的合成与抗肿瘤活性。

Chem Pharm Bull (Tokyo). 1989 Mar;37(3):688-91. doi: 10.1248/cpb.37.688.

Sparsomycin analogs. II. Synthesis and biological activities of 5-carboxy-6-methyluracil derivatives.稀疏霉素类似物。II. 5-羧基-6-甲基尿嘧啶衍生物的合成及生物活性

Chem Pharm Bull (Tokyo). 1983 Jan;31(1):135-43. doi: 10.1248/cpb.31.135.

Effect of sparsomycin analogues on the puromycin-peptidyl transferase reaction on ribosomes.稀疏霉素类似物对核糖体上嘌呤霉素 - 肽基转移酶反应的影响。

J Med Chem. 1978 Feb;21(2):176-9. doi: 10.1021/jm00200a006.

Importance of the hydrophobic sulfoxide substituent on nontoxic analogs of sparsomycin.疏水亚砜取代基对稀疏霉素无毒类似物的重要性。

Antimicrob Agents Chemother. 1984 Apr;25(4):443-5. doi: 10.1128/AAC.25.4.443.

The development of sparsomycin as an anti-tumour drug.sparsomycin作为一种抗肿瘤药物的研发。

Anticancer Drug Des. 1988 Mar;2(4):333-7.

Necessity of the sulfoxide moiety for the biochemical and biological properties of an analog of sparsomycin.亚砜部分对稀疏霉素类似物生化及生物学特性的必要性

Biochem Biophys Res Commun. 1983 Jul 18;114(1):1-7. doi: 10.1016/0006-291x(83)91585-1.

Synthesis and activity of pyrimidinylpropenamide antibiotics: the alkyl analogues of sparsomycin.

Biosci Biotechnol Biochem. 2003 Dec;67(12):2556-66. doi: 10.1271/bbb.67.2556.

Characterization of sparsomycin resistance in Streptomyces sparsogenes.产稀疏链霉菌中稀疏霉素抗性的特性分析

Antimicrob Agents Chemother. 2002 Sep;46(9):2914-9. doi: 10.1128/AAC.46.9.2914-2919.2002.

引用本文的文献

Sparsomycin Exhibits Potent Antiplasmodial Activity In Vitro and In Vivo.稀疏霉素在体外和体内均表现出强大的抗疟原虫活性。

Pharmaceutics. 2022 Feb 28;14(3):544. doi: 10.3390/pharmaceutics14030544.

Induction of Cryptic Antifungal Pulicatin Derivatives from by Microbial Co-Culture.通过微生物共培养诱导来自 Pulicaria 的隐色抗真菌衍生物。

Biomolecules. 2020 Feb 10;10(2):268. doi: 10.3390/biom10020268.

Characterization of sparsomycin resistance in Streptomyces sparsogenes.产稀疏链霉菌中稀疏霉素抗性的特性分析

Antimicrob Agents Chemother. 2002 Sep;46(9):2914-9. doi: 10.1128/AAC.46.9.2914-2919.2002.

Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes.抗肿瘤抗生素稀疏霉素及其衍生物与核糖体 - tRNA复合物中23S样rRNA肽基转移酶中心的A2602直接交联。

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9003-8. doi: 10.1073/pnas.96.16.9003.

Purification and preliminary characterization of (E)-3-(2,4-dioxo-6-methyl-5-pyrimidinyl)acrylic acid synthase, an enzyme involved in biosynthesis of the antitumor agent sparsomycin.（E）-3-（2,4-二氧代-6-甲基-5-嘧啶基）丙烯酸合酶的纯化及初步表征，该酶参与抗肿瘤药物稀疏霉素的生物合成。

J Bacteriol. 1997 Feb;179(4):1385-92. doi: 10.1128/jb.179.4.1385-1392.1997.

In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models.杀酶菌素及其类似物在八种小鼠肿瘤模型中的体内抗肿瘤活性。

Invest New Drugs. 1988 Dec;6(4):285-92. doi: 10.1007/BF00173646.

Interaction of the antibiotic sparsomycin with the ribosome.抗生素 sparsomycin 与核糖体的相互作用。

Antimicrob Agents Chemother. 1991 Jan;35(1):10-3. doi: 10.1128/AAC.35.1.10.

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