Nakagiri Ryusuke, Hashizume Erika, Kayahashi Shun, Sakai Yasushi, Kamiya Toshikazu
Kyowa Hakko Kogyo Co., Ltd., Tsukuba Research Laboratories, Ibaraki, Japan.
Biosci Biotechnol Biochem. 2003 Dec;67(12):2641-3. doi: 10.1271/bbb.67.2641.
Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SER. var. thunbergii MAKINO, suppressed D-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. The hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. Some fractionated extracts showed hepatoprotective activity in the D-galactosamine-induced in vitro liver injury model.
甜茶，即日本绣球（Hydrangea macrophylla SER. var. thunbergii MAKINO）经发酵和干燥后的叶子，在以1%的比例添加到大鼠饮食中并喂食15天后，对D-半乳糖胺诱导的肝损伤的抑制率达85.2%。其肝脏保护作用比水飞蓟提取物和姜黄粉更强。一些分级提取物在D-半乳糖胺诱导的体外肝损伤模型中显示出肝脏保护活性。
