Setzu Anna, Ffrench-Constant Charles, Franklin Robin J M
Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Glia. 2004 Feb;45(3):307-11. doi: 10.1002/glia.10321.
An important question relevant to developing remyelination therapies is whether axons that remain without myelin sheaths after an episode of demyelination retain myelination competence. To resolve this, we have developed a model of transplantation into the nerve fibre layer of the adult rat retina, where the axons are unmyelinated. In the adult, these axons can be myelinated by transplantation of both the oligodendrocyte progenitor cells (OPCs) and an OPC line (CG4). The extent of myelination achieved following transplantation of OPCs is the same in young adult recipients (2 months old) as that which occurs in old adult recipients (12-18 months old), indicating that there are no changes in axons remaining unmyelinated for many months that would prevent effective remyelination. This finding suggests that chronically demyelinated regions of axons such as those in seen in multiple sclerosis are likely to remain competent to be remyelinated.
与开发髓鞘再生疗法相关的一个重要问题是，在脱髓鞘发作后仍没有髓鞘的轴突是否保留髓鞘形成能力。为了解决这个问题，我们建立了一个移植到成年大鼠视网膜神经纤维层的模型，该层的轴突是无髓鞘的。在成年动物中，通过移植少突胶质前体细胞（OPC）和一个OPC系（CG4），这些轴突可以形成髓鞘。在年轻成年受体（2个月大）中，移植OPC后实现的髓鞘形成程度与老年成年受体（12 - 18个月大）中发生的程度相同，这表明许多个月一直无髓鞘的轴突没有变化，不会妨碍有效的髓鞘再生。这一发现表明，诸如在多发性硬化症中所见的轴突慢性脱髓鞘区域可能仍有进行髓鞘再生的能力。
