Blouin J, Spindler E, Perez E, Blouin A, Hotz S, Hakkaku J
Department of Psychiatry, Ottawa Civic Hospital, Ontario.
Can J Psychiatry. 1992 Dec;37(10):724-7. doi: 10.1177/070674379203701009.
Stress has been implicated as a major confounding factor in the interpretation of Dexamethasone Suppression Test (DST) results. This study was designed to examine the effects of stress on DST results. Fifty patients with high levels of acute, chronic, and environmental stress participated in the study. Each patient was given a comprehensive psychiatric and psychological assessment, a routine administration of dexamethasone, and blood tests of cortisol values. The results indicate that the three measures of stress do not appear to affect levels of cortisol suppression, however, all three measures of stress predicted depression. As expected, DST cortisol levels were related to depression. Results are discussed in terms of their implications for understanding the associations among stress, depression and DST results.
压力被认为是地塞米松抑制试验（DST）结果解读中的一个主要混杂因素。本研究旨在探讨压力对DST结果的影响。五十名急性、慢性和环境压力水平较高的患者参与了该研究。每位患者都接受了全面的精神和心理评估、地塞米松的常规给药以及皮质醇值的血液检测。结果表明，三种压力测量指标似乎并未影响皮质醇抑制水平，然而，所有三种压力测量指标都预测了抑郁。正如预期的那样，DST皮质醇水平与抑郁有关。讨论了这些结果对于理解压力、抑郁和DST结果之间关联的意义。
