Wang Li, Simpson Helen B, Dulawa Stephanie C
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Behav Pharmacol. 2009 Mar;20(2):119-33. doi: 10.1097/FBP.0b013e32832a80ad.
Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.
强迫症（OCD）是一种以不想要的、侵入性的想法、图像或冲动和/或重复行为为特征的疾病。强迫症是导致残疾的主要原因；然而，这种复杂的、异质性疾病背后的遗传因素和病理生理机制在很大程度上仍然未知。在过去十年中，为了研究这种疾病背后的神经机制并开发新的治疗方法，已经开发了许多假定的强迫症小鼠遗传模型。本文综述并评估了迄今为止的这些实验制剂。对使用基因敲除或转基因方法的模型，以及那些研究基因多样化群体变异的模型进行了评估和讨论。
