钙网蛋白：从钙离子结合到基因表达调控

Calreticulin: from Ca2+ binding to control of gene expression.

作者信息

Burns K, Atkinson E A, Bleackley R C, Michalak M

机构信息

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.

出版信息

Trends Cell Biol. 1994 May;4(5):152-4. doi: 10.1016/0962-8924(94)90190-2.

DOI:10.1016/0962-8924(94)90190-2

PMID:14731641

Abstract

Calreticulin is a highly conserved Ca(2+)-binding/storage protein of the endoplasmic reticulum (ER). Recently, it has been shown to play a role in the control of gene expression by interacting with the DNA-binding domain of various steroid receptors. How does this ER protein gain access to the nuclear steroid receptors? We propose that calreticulin undergoes unique intracellular trafficking that allows it to colocalize with and bind to steroid receptors.

摘要

钙网蛋白是内质网中一种高度保守的钙结合/储存蛋白。最近研究表明，它通过与多种类固醇受体的DNA结合域相互作用，在基因表达调控中发挥作用。这种内质网蛋白是如何接触到核类固醇受体的呢？我们推测，钙网蛋白经历了独特的细胞内运输过程，使其能够与类固醇受体共定位并结合。