Michalak M, Corbett E F, Mesaeli N, Nakamura K, Opas M
MRC Group in Molecular Biology of Membranes, Department of Biochemistry, University of Alberta, 3-56 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7.
Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):281-92.
The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of membrane-associated and secreted proteins. The membrane is also an important site of Ca(2+) storage and release. Calreticulin is a unique ER luminal resident protein. The protein affects many cellular functions, both in the ER lumen and outside of the ER environment. In the ER lumen, calreticulin performs two major functions: chaperoning and regulation of Ca(2+) homoeostasis. Calreticulin is a highly versatile lectin-like chaperone, and it participates during the synthesis of a variety of molecules, including ion channels, surface receptors, integrins and transporters. The protein also affects intracellular Ca(2+) homoeostasis by modulation of ER Ca(2+) storage and transport. Studies on the cell biology of calreticulin revealed that the ER membrane is a very dynamic intracellular compartment affecting many aspects of cell physiology.
内质网（ER）在膜相关蛋白和分泌蛋白的合成及伴侣作用中发挥着关键作用。内质网也是钙（Ca2+）储存和释放的重要场所。钙网蛋白是一种独特的内质网腔驻留蛋白。该蛋白在内质网腔内以及内质网环境之外都会影响许多细胞功能。在内质网腔内，钙网蛋白执行两项主要功能：伴侣作用和钙（Ca2+）稳态调节。钙网蛋白是一种高度通用的凝集素样伴侣蛋白，它参与多种分子的合成过程，包括离子通道、表面受体、整合素和转运蛋白。该蛋白还通过调节内质网钙（Ca2+）的储存和运输来影响细胞内钙（Ca2+）稳态。对钙网蛋白细胞生物学的研究表明，内质网膜是一个非常动态的细胞内区室，会影响细胞生理学的许多方面。
