蛋白质导入线粒体：两个系统协同作用？

Protein import into mitochondria: two systems acting in tandem?

作者信息

Glick B, Wachter C, Schatz G

机构信息

Biocenter, University of Basel, CH-4056, Basel, Switzerland.

出版信息

Trends Cell Biol. 1991 Oct;1(4):99-103. doi: 10.1016/0962-8924(91)90037-a.

DOI:10.1016/0962-8924(91)90037-a

PMID:14731796

Abstract

Mitochondria can import proteins from the cytoplasm at sites where the two mitochondrial membranes are closely apposed. However, each of these membranes contains a distinct protein translocation channel. Recent evidence suggests that the two types of channel are not permanently coupled, but may dissociate in a reversible manner. This reversible interaction is probably essential for intramitochondrial sorting proteins.

摘要

线粒体能够在两层线粒体膜紧密相邻的位点从细胞质中导入蛋白质。然而，每一层膜都含有一个独特的蛋白质转运通道。最近的证据表明，这两种类型的通道并非永久偶联，而是可能以可逆的方式解离。这种可逆相互作用可能对于线粒体内蛋白质分选至关重要。