Basheer R, Yang J, Tempel A
Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004.
Brain Res Dev Brain Res. 1992 Nov 20;70(1):145-8. doi: 10.1016/0165-3806(92)90113-b.
G alpha s mRNA levels were measured in brain regions of newborn pups following prenatal morphine treatment. A significant decrease (24%) in G alpha s mRNA levels was observed in the frontal cortex. No changes were observed in other regions. This report demonstrates the first in vivo study of opiate effects on G-protein gene expression in neonates. The development of tolerance in vivo may involve complex interactions between several neurotransmitter systems having opposing actions on the G-protein system.
在产前给予吗啡治疗后，对新生幼崽脑区的Gαs信使核糖核酸水平进行了测量。在额叶皮质观察到Gαs信使核糖核酸水平显著下降（24%）。在其他区域未观察到变化。本报告展示了第一项关于阿片类药物对新生儿G蛋白基因表达影响的体内研究。体内耐受性的发展可能涉及几种对G蛋白系统具有相反作用的神经递质系统之间的复杂相互作用。
