动物模型中产前阿片类药物暴露：当前研究结果和未来方向。
Modeling prenatal opioid exposure in animals: Current findings and future directions.
机构信息
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, United States.
Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, United States.
出版信息
Front Neuroendocrinol. 2018 Oct;51:1-13. doi: 10.1016/j.yfrne.2017.09.001. Epub 2017 Sep 28.
Abstract
The past decade has seen a drastic rise in the number of infants exposed to opioids in utero. It is unclear what lasting effect this exposure may have on these children. Animal models of prenatal opioid exposure may provide insight into potential areas of vulnerability. The present review summarizes the findings across animal models of prenatal opioid exposure, including exposure to morphine, methadone, buprenorphine, and oxycodone. Details regarding the drug, doses, and duration of treatment, as well as key findings, are summarized in tables with associated references. Finally, significant gaps in the current preclinical literature and future directions are discussed.
摘要
在过去的十年中，越来越多的婴儿在子宫内接触到阿片类药物。目前尚不清楚这种接触可能对这些儿童产生什么持久影响。产前阿片类药物暴露的动物模型可能为潜在的脆弱领域提供一些见解。本综述总结了产前阿片类药物暴露的动物模型的研究结果，包括暴露于吗啡、美沙酮、丁丙诺啡和羟考酮。关于药物、剂量和治疗持续时间的详细信息以及关键发现均以表格形式总结，并附有相关参考文献。最后，讨论了当前临床前文献中的重大空白和未来的研究方向。
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