Dunbar Robert C
Chemistry Department, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Mass Spectrom Rev. 2004 Mar-Apr;23(2):127-58. doi: 10.1002/mas.10074.
Blackbody infrared radiative dissociation (BIRD) describes the observation of ion-dissociation reactions at essentially zero pressure by the ambient blackbody radiation field, which is usually studied in the ion-trapping ion cyclotron resonance (ICR) mass spectrometer. A brief summary of the historical context and evolution is provided. Focussing on the quantitative observation of the temperature dependence of BIRD rates, methods are developed for connecting BIRD observations with activation parameters and dissociation thermochemistry. Three regimes are differentiated and described, comprising large molecules, small molecules, and intermediate-sized molecules. The different approaches to interpreting BIRD kinetics in those three regimes are discussed. In less than a decade since its inception, this approach to studying gas-phase ions has spread over a wide variety of applications, which are surveyed. Some major areas of activity are: the characterization of solvent-molecule detachment from solvated ions; dissociation reactions of biomolecules (polypeptides, oligonucleotides, complexes involving polysaccharides) and the structural information to be deduced from them; and dissociations of proton-bound and metal-ion-containing complexes. Studies of blackbody-radiation-driven evaporation of water molecules from large water-cluster ions are surveyed briefly. Several techniques related to BIRD are noted, including collisional dissociation in the FT-ICR ion trap; high-pressure thermal dissociation in quadrupole ion traps and in heated inlet capillary regions; hot-filament-assisted dissociation; and infrared multiphoton dissociation (IRMPD).
黑体红外辐射解离（BIRD）描述了在基本为零的压力下，由周围黑体辐射场引发的离子解离反应的观测现象，该现象通常在离子阱离子回旋共振（ICR）质谱仪中进行研究。本文提供了该方法的历史背景和发展历程的简要概述。重点关注BIRD速率对温度依赖性的定量观测，开发了将BIRD观测结果与活化参数及解离热化学相联系的方法。区分并描述了三种情况，包括大分子、小分子和中等大小的分子。讨论了在这三种情况下解释BIRD动力学的不同方法。自其诞生以来不到十年间，这种研究气相离子的方法已广泛应用于多种领域，本文对此进行了综述。一些主要的研究领域包括：溶剂化离子中溶剂分子脱离的表征；生物分子（多肽、寡核苷酸、涉及多糖的复合物）的解离反应以及从中推断出的结构信息；质子结合复合物和含金属离子复合物的解离。简要综述了黑体辐射驱动大的水簇离子中水分子蒸发的研究。介绍了几种与BIRD相关的技术，包括傅里叶变换离子回旋共振（FT-ICR）离子阱中的碰撞解离；四极杆离子阱和加热进样毛细管区域中的高压热解离；热丝辅助解离；以及红外多光子解离（IRMPD）。
