Hedrick Philip W, Lee Rhonda N, Buchanan Colleen
School of Life Sciences, Arizona State University, Tempe, Arizona 85287-4501, USA.
J Wildl Dis. 2003 Oct;39(4):909-13. doi: 10.7589/0090-3558-39.4.909.
The endangered Mexican wolf (Canis lupus baileyi) was recently reintroduced into Arizona and New Mexico (USA). In 1999 and 2000, pups from three litters that were part of the reintroduction program died of either canine parvovirus or canine distemper. Overall, half (seven of 14) of the pups died of either canine parvovirus or canine distemper. The parents and their litters were analyzed for variation at the class II major histocompatibility complex (MHC) gene DRB1. Similar MHC genes are related to disease resistance in other species. All six of the surviving pups genotyped for the MHC gene were heterozygous while five of the pups that died were heterozygous and one was homozygous. Resistance to pathogens is an important aspect of the management and long-term survival of endangered taxa, such as the Mexican wolf.
濒危的墨西哥狼（Canis lupus baileyi）最近被重新引入美国亚利桑那州和新墨西哥州。在1999年和2000年，作为重新引入计划一部分的三窝幼崽死于犬细小病毒或犬瘟热。总体而言，一半（14只中的7只）幼崽死于犬细小病毒或犬瘟热。对这些幼崽的父母及其幼崽进行了II类主要组织相容性复合体（MHC）基因DRB1的变异分析。其他物种中，类似的MHC基因与抗病性有关。对MHC基因进行基因分型的所有6只存活幼崽都是杂合子，而死亡的幼崽中有5只是杂合子，1只是纯合子。对病原体的抗性是濒危物种（如墨西哥狼）管理和长期生存的一个重要方面。
