Zhou Min, Bentley David, Ghosh Indraneel
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA.
J Am Chem Soc. 2004 Jan 28;126(3):734-5. doi: 10.1021/ja036634y.
We describe a new family of discrete supramolecules comprising leucine-zipper peptides noncovalently assembled upon cognate leucine zippers fused to a dendrimer core. Circular dichroism and sedimentation equilibrium experiments clearly demonstrate that each leucine-zipper dendrimer (D-EZ4 or D-KZ4) can noncovalently display four leucine zippers on their surface that can be utilized for the multivalent display of protein cargo. Furthermore, we show that matched leucine-zipper dendrimers (D-EZ4/D-KZ4) can self-organize into fibers at neutral pH, providing a new scaffold for nanotechnology.
