Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7396-417. doi: 10.1002/anie.201201040.
Hybrid biomaterials are systems created from components of at least two distinct classes of molecules, for example, synthetic macromolecules and proteins or peptide domains. The synergistic combination of two types of structures may produce new materials that possess unprecedented levels of structural organization and novel properties. This Review focuses on biorecognition-driven self-assembly of hybrid macromolecules into functional hydrogel biomaterials. First, basic rules that govern the secondary structure of peptides are discussed, and then approaches to the specific design of hybrid systems with tailor-made properties are evaluated, followed by a discussion on the similarity of design principles of biomaterials and macromolecular therapeutics. Finally, the future of the field is briefly outlined.
杂化生物材料是由至少两类不同分子成分构成的系统，例如，合成大分子和蛋白质或肽结构域。两种类型结构的协同组合可能产生具有前所未有的结构组织和新颖性能的新材料。本综述重点关注基于生物识别的杂化大分子自组装成功能性水凝胶生物材料。首先，讨论了控制肽二级结构的基本规则，然后评估了具有定制性质的杂化系统的特定设计方法，接着讨论了生物材料和高分子治疗剂设计原则的相似性。最后，简要概述了该领域的未来发展方向。
